Modified PNA Monomers
The biggest advantage of PNAs compared to DNA and RNA is their neutral backbone which brings about that hybridization interactions such as H-bonding and base stacking are not partially offset by repulsive electrostatic interactions as is the case with the chemically charged phosphoribosyl backbones. A drawback of this unique feature is the resulting to poorer aqueous solubility and the tendency to aggregate. To overcome this shortcoming, modifications on the backbone were introduced. The most common position for modification on the backbone is the gamma position. The synthesis of gamma-modified PNA monomers is based on amino acids bearing exclusively heteroatoms.
At ASM Boc/Cbz-gamma-PNA and Fmoc/Boc-gamma-PNA monomers are synthesized mostly from both enantiomers of serine and readily available in g quantities within 3-4 weeks after placing the order and with guaranteed > 98% enantiomeric purity.
Furthermore we have experience in producing a large number of modified PNA monomers with different protecting groups (Cl-Bhoc, 4-OMeCbz, Teoc, Boc, Fmoc) and base modifications (thioU, J, etc.).
We encourage you to contact us for special requests.
Modified PNA Monomers | ||||
Structure | Common Name | Product No. | Quantity | EUR |
Boc-PNA-thioU(PMB)-OH | 5004055 | 1 g | Please inquire | |
Boc-PNA-J(Z)-OH | 5004043 | 1 g | 350 | |
Guanidino-G-Clamp-PNA | 5004079 | 1 g | Please inquire | |
Boc-gamma-L-Ser(Me)-PNA-T-OH | 5004056 | 1 g | Please inquire | |
Boc-gamma-L-Ser(Me)-PNA-C(Cbz)-OH | 5004057 | 1 g | Please inquire | |
Boc-gamma-L-Ser(Me)-PNA-A(Cbz)-OH | 5004058 | 1 g | Please inquire | |
Boc-gamma-L-Ser(Me)-PNA-G-OH | 5004059 | 1 g | Please inquire | |
Boc-gamma-D-Ser(Me)-PNA-T-OH | 5004060 | 1 g | Please inquire | |
Boc-gamma-D-Ser(Me)-PNA-C(Cbz)-OH | 5004061 | 1 g | Please inquire | |
Boc-gamma-D-Ser(Me)-PNA-A(Cbz)-OH | 5004062 | 1 g | Please inquire | |
Boc-gamma-D-Ser(Me)-PNA-G-OH | 5004063 | 1 g | Please inquire | |
Boc-gamma-L-Ser(Bn)-PNA-T-OH | 5004072 | 1 g | Please inquire | |
Boc-gamma-L-Ser(Bn)-PNA-C-OH | 5004073 | 1 g | Please inquire | |
Boc-gamma-L-Ser(Bn)-PNA-A-OH | 5004074 | 1 g | Please inquire | |
Boc-gamma-L-Ser(Bn)-PNA-T-OH | 5004075 | 1 g | Please inquire | |
Our prices are quoted ex-VAT. Any applicable tax and duties will be supported by the buyer. All other costs as for example freight and insurance are charged separately and depend on the order size and shipping address. |