Modified PNA Monomers

The biggest advantage of PNAs compared to DNA and RNA is their neutral backbone which brings about that hybridization interactions such as H-bonding and base stacking are not partially offset by repulsive electrostatic interactions as is the case with the chemically charged phosphoribosyl backbones. A drawback of this unique feature is the resulting to poorer aqueous solubility and the tendency to aggregate. To overcome this shortcoming, modifications on the backbone were introduced. The most common position for modification on the backbone is the gamma position. The synthesis of gamma-modified PNA monomers is based on amino acids bearing exclusively heteroatoms.

At ASM Boc/Cbz-gamma-PNA and Fmoc/Boc-gamma-PNA monomers are synthesized mostly from both enantiomers of serine and readily available in g quantities within 3-4 weeks after placing the order and with guaranteed > 98% enantiomeric purity.

Furthermore we have experience in producing a large number of modified PNA monomers with different protecting groups (Cl-Bhoc, 4-OMeCbz, Teoc, Boc, Fmoc) and base modifications (thioU, J, etc.).

We encourage you to contact us for special requests.

Modified PNA Monomers

Structure

Common Name

Product No.

Quantity

EUR

Boc-PNA-thioU(PMB)-OH
(Boc-thioU(PMB)-Aeg-OH)
C23H30N4O7S
MW: 506,6
CAS: n/a

5004055

1 g
10 g
25 g
>25 g

Please inquire

Boc-PNA-J(Z)-OH
(Boc-J(Z)-Aeg-OH)
C23H29N5O8
MW: 503,51
CAS: 144564-94-3

5004043

1 g
10 g
25 g
>25 g

350
3.150
7.400
on request

Guanidino-G-Clamp-PNA
C50H46N8O12
MW: 950,96
CAS: n/a

5004079

1 g
10 g
>10 g

Please inquire

Boc-gamma-L-Ser(Me)-PNA-T-OH
C18H28N4O8
MW: 428,44
CAS: n/a

5004056

1 g
10 g
>10 g

Please inquire

Boc-gamma-L-Ser(Me)-PNA-C(Cbz)-OH
C25H33N5O9
MW: 547,57
CAS: n/a

5004057

1 g
10 g
>10 g

Please inquire

Boc-gamma-L-Ser(Me)-PNA-A(Cbz)-OH
C26H33N7O8
MW: 571,59
CAS: n/a

5004058

1 g
10 g
>10 g

Please inquire

Boc-gamma-L-Ser(Me)-PNA-G-OH
C27H34N6O9
MW: 586,60
CAS: n/a

5004059

1 g
10 g
>10 g

Please inquire

Boc-gamma-D-Ser(Me)-PNA-T-OH
C18H28N4O8
MW: 428,44
CAS: n/a

5004060

1 g
10 g
>10 g

Please inquire

Boc-gamma-D-Ser(Me)-PNA-C(Cbz)-OH
C25H33N5O9
MW: 547,57
CAS: n/a

5004061

1 g
10 g
>10 g

Please inquire

Boc-gamma-D-Ser(Me)-PNA-A(Cbz)-OH
C26H33N7O8
MW: 571,59
CAS: n/a

5004062

1 g
10 g
>10 g

Please inquire

Boc-gamma-D-Ser(Me)-PNA-G-OH
C27H34N6O9
MW: 586,60
CAS: n/a

5004063

1 g
10 g
>10 g

Please inquire

Boc-gamma-L-Ser(Bn)-PNA-T-OH
C24H32N4O8
MW: 504,54
CAS: n/a

5004072

1 g
10 g
>10 g

Please inquire

Boc-gamma-L-Ser(Bn)-PNA-C-OH
C31H37N5O9
MW: 623,66
CAS: n/a

5004073

1 g
10 g
>10 g

Please inquire

Boc-gamma-L-Ser(Bn)-PNA-A-OH
C32H37N7O8
MW: 647,69
CAS: n/a

5004074

1 g
10 g
>10 g

Please inquire

Boc-gamma-L-Ser(Bn)-PNA-T-OH
C32H37N7O9
MW: 663,69
CAS: n/a

5004075

1 g
10 g
>10 g

Please inquire

Our prices are quoted ex-VAT. Any applicable tax and duties will be supported by the buyer. All other costs as for example freight and insurance are charged separately and depend on the order size and shipping address.
License Statement: PNA Monomers are made and sold pursuant to license under one or more of US Patents Nos. US 5,773,571, US 6,133,444, US 6,172,226, US 6,395,474, US 6,414,112, US 6,613,873, US 6,710,163 and US 6,713,602, or corresponding patent claims outside the US and are provided only for use in academic and commercial research and not for any commercial purposes. Information about licenses for commercial use of PNA Monomers is available from the PNA Inventor Group.e-mail: pnainventorgroup@yahoo.dk