PNAs can be synthesized from the corresponding Fmoc-protected peptide nucleic acid monomers manually on solid phase or automated on peptide synthesizers using standard Fmoc chemistry. In continuous automated Fmoc-based solid phase synthesis of PNA-peptide oligomers, Fmoc/Bhoc-protected PNA monomers are preferred, since this allows for acid-catalyzed deprotection of all protecting groups plus simultaneous cleavage from the resin.
It is therefore not surprising, that our Fmoc/Bhoc-PNA monomers are a top seller at ASM with guaranteed high purity and solubility for all our monomers.
However, due to the somewhat reduced solubility of the Fmoc/Bhoc-protected PNA monomers, especially the Fmoc-PNA-G(Bhoc)-OH and the Fmoc-PNA-C(Bhoc)-OH which tend to precipitate when stored in solution, as an experienced PNA manufacturer, ASM also offers the corresponding Fmoc/Boc-protected PNA monomers on request.
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Fmoc PNA Monomers
Our prices are quoted ex-VAT. Any applicable tax and duties will be supported by the buyer. All other costs as for example freight and insurance are charged separately and depend on the order size and shipping address.