Originally, PNA oligomers were synthesized by solid-phase methods involving the aggregation of the corresponding PNA monomers bearing Boc/Cbz protecting groups. Although they require harsh reaction conditions for deprotection and cleavage (usually HF or TFA and hydrogen), the PNAs can more easily be purified as both protecting groups have volatile, hence easily removable by-products.
ASM has been manufacturing Boc-modified PNA monomers for the past 15 years. Our Boc/Cbz-PNA monomers can be ordered from stock in up to 50 g quantities.
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Boc PNA Monomers
Our prices are quoted ex-VAT. Any applicable tax and duties will be supported by the buyer. All other costs as for example freight and insurance are charged separately and depend on the order size and shipping address.